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Filtered Search Results
Medchemexpress LLC Methyl tetracosanoate | 2442-49-1 | MFCD00009351 | 250 MG
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Methyl tetracosanoate, also known as Methyl lignocerate, is a fatty acid methyl ester primarily recognized for its anti-diabetic activity. This compound has demonstrated the ability to increase glucose uptake in differentiated 3T3-L1 adipocytes and elevates GLUT4 mRNA expression.
- Increases glucose uptake on differentiated 3T3-L1 adipocytes
- Elevates GLUT4 mRNA expression
- Purity of 98.0%
- Solid appearance
- White to off-white color
- Stable for 3 years at room temperature (solid form)
- Solutions stable for 2 years at -80°C or 1 year at -20°C
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Medchemexpress LLC AC 187 | 151804-77-2 | 98.9% | 2890.21 | 10 MG
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AC 187 is a potent and orally active amylin receptor antagonist. It demonstrates high selectivity for the amylin receptor compared to calcitonin and CGRP receptors. This compound exhibits neuroprotective effects by blocking amyloidβ protein (Aβ)-induced neurotoxicity and improving neuronal survival.
- Potent and orally active amylin receptor antagonist
- High selectivity for the amylin receptor
- Exhibits neuroprotective effects
- Blocks amyloidβ protein (Aβ)-induced neurotoxicity
- Improves neuronal survival
- Attenuates activation of caspases mediating Aβ-induced apoptotic cell death
- Increases glucagon concentration
- Accelerates gastric emptying of liquids
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Medchemexpress LLC Sulfamethoxypyridazine | 80-35-3 | 99.9% | 250 MG
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Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic primarily used for the treatment of Dermatitis herpetiformis. It is intended for research use only and not for sale to patients. This compound is available in solid form and is stable under recommended storage conditions, making it suitable for various laboratory applications.
- Used for treatment of dermatitis herpetiformis
- Long-acting sulfonamide antibiotic
- Intended for research use only
- Stable under recommended storage conditions
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Medchemexpress LLC Mitiglinide calcium | 145525-41-3 | 98.8% | 334.44 | 250 MG
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Mitiglinide calcium, an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. It is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel) and can be used for the research of type 2 diabetes.
- Inhibits Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) in COS-1 cells.
- Suppresses the increase in plasma glucose levels after a meal load and the area under the curve for plasma glucose levels (AUCglucose).
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Medchemexpress LLC 5-acetylthiophene-2-carboxamide | 68257-89-6 | MFCD07774222 | 250mg
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Arolol impurity 4 is a drug impurity
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Medchemexpress LLC 3-Azidopropylamine | 88192-19-2 | MFCD11046568 | C3H8N4 | 250 MG
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3-Azidopropylamine is a click chemistry reagent containing an azide group. It is utilized for the complexation and transfection of plasmid DNA by reacting with the starch sugar of potato starch. This reagent facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.
- Click chemistry reagent
- Contains an azide group
- Reacts with starch sugar for complexation and transfection of plasmid DNA
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in ring strain-promoted alkyne-azide cycloaddition (SPAAC)
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Medchemexpress LLC Ethyl diethoxyacetate | 6065-82-3 | 176.21 | 25 G
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Ethyl diethoxyacetate is an organic synthesis reagent that shows moderate antiproliferative effects on cervical cancer and liver cancer. It is a liquid with a relative density of 0.985 g/cm3, stable under recommended storage conditions, and is for research use only.
- Used as an organic synthesis reagent
- Exhibits moderate antiproliferative effects on cervical cancer and liver cancer
- Liquid appearance
- Stable under recommended storage conditions
- Suitable for laboratory chemical applications
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Medchemexpress LLC GLPG3970 | 2403733-82-2 | C25H27F3N4O4 | 250 MG
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GLPG3970 is a first-in-class SIK2/SIK3 inhibitor intended for research related to inflammation and autoimmune diseases. It has been investigated in clinical trials for conditions such as Systemic Lupus Erythematosus, Ulcerative Colitis, and Rheumatoid Arthritis.
- Acts as a SIK2/SIK3 inhibitor
- Supports research in inflammation and autoimmune diseases
- Induces IL-10 expression in human CD14+ monocytes with an EC50 of 1087 nM
- Reduces LPS-stimulated TNF-alpha production in human CD14+ monocytes with an IC50 of 133 nM
- Decreases ear thickness in murine models of psoriatic-like epidermal hyperplasia
- Improves clinical manifestations in murine collagen-antibody induced arthritis models
- Reduces disease activity index in mice T cell transfer models
- Investigated in clinical trials for various conditions
- High purity: 99.70%
- Solid, white to off-white appearance
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Medchemexpress LLC Benzenepropanoic acid, 4-methoxy-, ethyl ester | 22767-72-2 | 250 MG
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Ethyl-p-methoxyhydrocinnamate is a compound identified as Benzenepropanoic acid, 4-methoxy-, ethyl ester. This product has a purity of 97.64% by HPLC and appears as a colorless to light yellow liquid. It is suitable for various laboratory applications requiring high purity.
- High purity: 97.64% (HPLC)
- Appearance: Colorless to light yellow liquid
- Molecular formula: C12H16O3
- Molecular weight: 208.26
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Medchemexpress LLC Grape seed extract | 84929-27-1 | 250 MG
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Grape seed extract is a natural product with anti-inflammatory and anti-proliferative effects. It shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase, and induces apoptosis in human colorectal cancer cells.
- Natural product
- Anti-inflammatory and anti-proliferative effects
- Inhibits fat-metabolizing enzymes
- Induces apoptosis in human colorectal cancer cells
- Inhibits growth and induces death in human colorectal cancer cells
- Modulates protein levels of cell cycle regulatory molecules
- Inhibits HT29 colon carcinoma tumor xenograft growth in athymic nude mice
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Medchemexpress LLC Quininic acid | 86-68-0 | 250 MG
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Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid. It represents up to 86.3% of all organic acids and acts as an astringent and starting material for the synthesis of new pharmaceuticals. It is intended for research use only.
- Purified from Eucalyptus globulus, cinchona bark, and other plant products
- Most abundant organic acid, representing up to 86.3% of all organic acids
- Acts as an astringent
- Starting material for the synthesis of new pharmaceuticals
- Solid form, white to yellow color
- High purity of 99.94%
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Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 1 MG
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N2,N2-Dimethylguanosine is a methylated nucleoside found in RNA and tRNA. It interferes with reverse transcriptase-mediated cDNA synthesis and impacts high-throughput RNA sequencing efficiency. The compound can be selectively demethylated by AlkB mutant enzymes into N2-methylguanosine, which helps to reduce reverse transcription hindrance.
- Methylated nucleoside present in RNA and tRNA.
- Hinders reverse transcriptase-mediated cDNA synthesis.
- Affects sequencing efficiency in high-throughput RNA sequencing.
- Can be converted to N2-methylguanosine by AlkB mutant enzymes to reduce reverse transcription hindrance.
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Medchemexpress LLC Cholest-4-en-3-one | 601-57-0 | 99.8% | 384.64 | 250 MG
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Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent metabolized primarily in the liver as an intermediate oxidation product of cholesterol. It inhibits human dermal fibroblast migration and combats Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also helps alleviate metabolic disorders caused by obesity in db/db mice.
- Orally available antimicrobial agent
- Metabolized as an intermediate oxidation product of cholesterol
- Inhibits human dermal fibroblast migration
- Combats Helicobacter pylori infection in vitro and in mouse models
- Alleviates metabolic disorders caused by obesity in db/db mice
- Reduces plasma cholesterol levels in dogs and chickens
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Medchemexpress LLC Salicyluric acid | 487-54-7 | 99.8% | 195.17 | 250 MG
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Salicyluric acid is an endogenous metabolite, exclusively for research purposes and not intended for patient use. This product is provided as a solid, white to off-white in appearance, with a molecular weight of 195.17. It is classified under phenols, monophenols, ketones, aldehydes, and acids, targeting both microbial and human endogenous metabolites.
- Molecular weight: 195.17
- Formula: C9H9NO4
- CAS no.: 487-54-7
- Appearance: Solid
- Color: White to off-white
- Structure classification: Phenols, monophenols, ketones, aldehydes, acids
- Initial source: Endogenous metabolite
- Target: Endogenous metabolite
- Pathway: Metabolic enzyme/protease
- Shipping: Room temperature in continental US; may vary elsewhere
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
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![Medchemexpress LLC 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- | 871258-12-7 | 99.5% | 616.06 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439908-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- | 871258-12-7 | 99.5% | 616.06 | 250 MG
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DLinDMA is an ionizable cationic lipid that serves as a key lipid component and benchmark for stable nucleic acid lipid particles (SNALPs). It is utilized for siRNA delivery. The structure of DLinDMA consists of three primary regions: the hydrocarbon chains, the linker, and the headgroup. It has demonstrated virtually indistinguishable blood pharmacokinetic profiles in mice.
- Ionizable cationic lipid
- Key lipid component of stable nucleic acid lipid particles (SNALPs)
- Used for siRNA delivery
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